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The Office of Naval Research (ONR) Human and Bioengineered Systems Division's mission is to direct, plan, foster and encourage science and technology in cognitive science, computational neuroscience, bio-mimetic technology, biophysics, social/organizational science, training, science of learning, human factors, and decision making as related to Naval needs.

The aim of Bio-Inspired Autonomous Systems is to extract principles of sensorimotor control, biomechanics and fluid dynamics of underwater propulsion and control in aquatic and amphibious animals that underlie the agility, stealth, efficiency and sensory adaptations of these animals.

The Cognitive Science for Human Machine Teaming program seeks to develop empirically grounded models of human cognition and computational architectures that attain human-level intelligence.

The Command Decision Making program is advancing cognitive theory and computational modeling to create decision support tools for warfighters that are mission and task sensitive, and therefore proactive in providing relevant information at appropriate times.

The Computational Neuroscience program aims to extract the computational principles of real neural circuits and systems to create novel, more powerful algorithms for pattern recognition and control.

The Human Interaction with Autonomous Systems program aims to create cognitively-compatible intelligent autonomous systems and robots that could serve as teammates with humans, enabling peer-to-peer collaboration among humans, robots, intelligent agents and autonomous systems.

The Human Performance, Training and Education (HPT&E) program is focused on developing scalable and effective science and technology solutions for Marine Corps Infantry / close combat forces during training and education pipelines, and operations focused upon Small Unit Dominance within the Fleet / Force.

The Manpower, Personnel, Training and Education Information Sciences portfolio funds basic research, applied research and advanced technology development in metrics development, data ontology, data mining and machine learning to optimize performance, manpower modelling, personnel screening, training and education opportunities for the warfighter within the Naval enterprise.

Analytics, Modeling and Simulation for Local and Regional Situation Awareness supports the development of data, analytics, decision tools, and models to support combatant commands in comprehensive understanding of mission environments, together with modeling and simulation efforts to improve wargaming and exercises.

Tactical Artificial Intelligence (AI) for Marine Corps focuses on advanced research into modeling and simulation with a specific emphasis on developing decision aids at the tactical level to support Marine Corps small unit decision making.